When someone hears they have abnormal protein in their blood, it can be confusing and even a little scary.
So, what does abnormal protein in blood mean exactly? It usually points to an issue with how the body is processing or producing proteins.
These proteins can tell doctors a lot about what’s going on inside the body, especially the immune system, kidneys, and liver. Blood proteins help with clotting, fighting infections, and transporting substances.
When there’s too much or too little of these proteins, or if they appear in unusual forms, it can suggest that something isn’t functioning as it should.
What Causes Abnormal Protein Levels in the Blood?
According to research by Arakawa, SJ. Prestrelski, W.C. Kenney, several health conditions can cause abnormal levels of protein in the blood. Some are temporary or minor, while others may need long-term attention.
| Cause | Description | Common Protein Affected |
| Dehydration | Less water in the bloodstream makes protein levels seem higher | Total protein |
| Infections | Immune response can spike protein production | Immunoglobulins |
| Chronic inflammation | Long-term inflammation causes certain proteins to increase | C-reactive protein |
| Liver disease | The liver makes most blood proteins, so damage affects levels | Albumin, globulin |
| Kidney disease | Protein may leak into urine, reducing blood protein levels | Albumin |
| Multiple myeloma | A cancer of plasma cells leading to unusual proteins in the blood | M protein |
If your protein levels are off, it doesn’t always mean something serious, but it’s a sign that your body may need attention.
Learn more about why females have less blood than males here.
Key Blood Proteins to Watch
Doctors look at specific proteins to understand your health better. Here are a few key ones:
- Albumin: Helps keep fluid in your bloodstream.
- Globulin: Includes antibodies that fight infection.
- Fibrinogen: Helps with blood clotting.
- C-reactive protein (CRP): Rises with inflammation.
An imbalance in these can provide clues. For example, low albumin may point to kidney or liver problems, while high CRP may signal an infection or inflammation.
Learn more about the blood group diet chart here.
Common Tests to Detect Abnormal Protein
When your doctor suspects protein issues, they may order a total protein test or a serum protein electrophoresis test. These tests measure the amount and types of protein in the blood.
- Total Protein Test: Measures combined levels of albumin and globulin.
- Serum Protein Electrophoresis (SPEP): Separates proteins into different groups to find any unusual patterns, such as the M protein in multiple myeloma.
- Urine Protein Test: Often done if kidney disease is suspected, to check if protein is leaking from the blood into the urine.
Routine blood tests can uncover abnormal protein levels even before symptoms start—don’t skip your annual checkup.
Learn more about blood protein levels and cancer here.
Symptoms That May Come With Abnormal Blood Protein
Sometimes abnormal proteins don’t cause symptoms at all, especially in the early stages. But if there are symptoms, they could include:
- Fatigue
- Swelling in hands, feet, or face (edema)
- Unexpected weight loss
- Bone pain (especially in cases like multiple myeloma)
- Frequent infections
- Trouble concentrating or confusion
If any of this sounds familiar, it’s a good idea to talk to your doctor.
Learn more about how to know your blood type at home here.
What Does Abnormal Protein in Blood Mean for Long-Term Health?
According to Clinical Chemistry, the meaning of abnormal protein in the blood depends on what’s causing the issue.
In mild cases like dehydration or a temporary infection, the protein levels usually return to normal with proper treatment or hydration.
But in more serious cases like chronic kidney disease, autoimmune disorders, or multiple myeloma, abnormal protein levels might be part of an ongoing condition. That’s why follow-up testing is often important.
If you’ve been told your protein levels are abnormal, ask for a breakdown of the specific proteins—it can help uncover the real cause.
Learn more about foods that cause blood sugar to rise here.
Treatment and Next Steps
A small 2010 study found that treatment depends on the underlying cause. For instance:
- Infections may need antibiotics or antiviral medication.
- Inflammation can be managed with anti-inflammatory drugs.
- Kidney disease may require diet changes, medication, or dialysis.
- Liver disease treatment can range from lifestyle changes to medication.
- Multiple myeloma or cancer-related proteins often need more specialized treatment, like chemotherapy or targeted therapy.
Doctors will often repeat the test or run additional labs before starting treatment.
Learn more about what protein in urine means medically here.
How to Maintain Healthy Protein Levels in Blood
Keeping protein levels in a healthy range doesn’t require a drastic lifestyle change, but a few habits can help.
- Stay hydrated—this affects how your blood reads in lab results.
- Eat a balanced diet with adequate protein.
- Avoid high alcohol intake, which can affect liver function.
- Keep blood pressure and blood sugar levels in check to protect the kidneys.
Good hydration and balanced nutrition are the first steps toward healthy blood protein levels.
Learn more about how much lean protein I should eat here.
A Word from GetMe Treated
Understanding what does abnormal protein in blood mean is important for managing your health. It might be nothing serious, or it could be a useful clue your body is sending.
With the right testing and medical advice, you can get a clearer picture and take the right steps toward balance and well-being.
If you’ve recently had blood work that shows abnormal protein levels, don’t panic. Ask questions, follow up with your doctor, and stay proactive about your health.
Learn more about which vegetables have the highest protein content here.
FAQs About What Does Abnormal Protein in Blood Mean
What does an abnormal protein in the blood mean if I feel fine?
Even if you feel okay, abnormal proteins may signal early signs of a hidden condition. Follow-up testing can help confirm if it’s temporary or something more serious.
Is an abnormal protein in the blood always cancerous?
No. It can be caused by many things, including infection, inflammation, or even dehydration. Cancer is just one of several possibilities.
Can abnormal blood protein be reversed?
Yes, depending on the cause. Treating the underlying issue often brings protein levels back to normal.
How serious is abnormal protein in the blood?
It ranges from mild to serious. The context, type of protein, and other lab results help doctors determine the next steps.
Can I test for abnormal blood protein at home?
Not accurately. These tests need to be done through a lab for reliable results.
Should I be worried if my doctor orders a protein electrophoresis test?
Not necessarily. It just means your doctor wants a closer look at your protein levels to understand your health better.